› 7jxn

X-ray diffraction
2Å resolution

Beta hairpin derived from Abeta17-36 with an F20Cha mutation

Released:
DOI: 10.2210/pdb7jxn/pdb
PDB entry 7jxn coloured by chain, front view.
PDB entry 7jxn coloured by chain, side view.
PDB entry 7jxn coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Phenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by β-Hairpins Derived from Aβ.
Haerianardakani S, Kreutzer AG, Salveson PJ, Samdin TD, Guaglianone GE, Nowick JS
J Am Chem Soc 142 20708-20716 (2020)
PMID: 33237748

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-138395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
P3(40) Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 21 amino acids
Theoretical weight: 2.2 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P05067 (Residues: 686-706; Coverage: 3%)
Gene names: A4, AD1, APP
Sequence domains: Beta-amyloid peptide (beta-APP)

Ligands and Environments

2 bound ligands:
Ligand CL 2 x CL
Ligand NA 1 x NA
2 modified residues:
Ligand ORN 8 x ORN
Ligand H7V 4 x H7V

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P63
Unit cell:
a: 37.167Å b: 37.167Å c: 116.994Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.283 0.277 0.301
Expression system: Not provided

Quick links

Citations

1 review citation

Exploring amyloid oligomers with peptide model systems.
Samdin et al. (2021)
5 other articles

1 mention without citation

Phenylalanine Mutation to Cyclohexylalanine Facilitates Triangular Trimer Formation by β-Hairpins Derived from Aβ.
Haerianardakani et al. (2020)