Function and Biology

Solution NMR structure of human Brd3 ET complexed with NSD3(148-184) peptide

Source organism: Homo sapiens
Biochemical function: not assigned
Biological process: not assigned
Cellular component: not assigned

EC 2.1.1.371: [Histone H3]-lysine(27) N-dimethyltransferase

Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(27) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(27)
Systematic name:
S-adenosyl-L-methionine:[histone H3]-L-lysine(27) N(6)-dimethyltransferase

EC 2.1.1.370: [Histone H3]-lysine(4) N-dimethyltransferase

Reaction catalysed:
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(4) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(4)
Systematic name:
S-adenosyl-L-methionine:[histone H3]-L-lysine(4) N(6)-dimethyltransferase

GO terms

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Sequence family

Pfam Protein family (Pfam)
PF17035
Domain description: Bromodomain extra-terminal - transcription regulation
Occurring in:
  1. Bromodomain-containing protein 3
The deposited structure of PDB entry 7jyn contains 1 copy of Pfam domain PF17035 (Bromodomain extra-terminal - transcription regulation) in Bromodomain-containing protein 3. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR027353
Domain description: NET domain
Occurring in:
  1. Bromodomain-containing protein 3
IPR038336
Domain description: NET domain superfamily
Occurring in:
  1. Bromodomain-containing protein 3