› 7jz5

X-ray diffraction
1.57Å resolution

Cellular retinol-binding protein 2 (CRBP2) in complex with 1-arachodonoyl-1-thio-glycerol

Released:
DOI: 10.2210/pdb7jz5/pdb
PDB entry 7jz5 coloured by chain, front view.
PDB entry 7jz5 coloured by chain, side view.
PDB entry 7jz5 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands.
Silvaroli JA, Plau J, Adams CH, Banerjee S, Widjaja-Adhi MAK, Blaner WS, Golczak M
OpenAccess logo J Lipid Res 62 100054 (2021)
PMID: 33631211

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156128 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Retinol-binding protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 138 amino acids
Theoretical weight: 16.2 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50120 (Residues: 1-134; Coverage: 100%)
Gene names: CRBP2, RBP2
Sequence domains: Lipocalin / cytosolic fatty-acid binding protein family

Ligands and Environments

1 bound ligand:
Ligand VPY 2 x VPY
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P212121
Unit cell:
a: 57.816Å b: 67.562Å c: 89.477Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.161 0.183
Expression system: Escherichia coli

Quick links

Citations

1 review citation

Retinol-binding protein 2 (RBP2): More than just dietary retinoid uptake.
Plau et al. (2022)
6 other articles

1 mention without citation

Molecular basis for the interaction of cellular retinol binding protein 2 (CRBP2) with nonretinoid ligands.
Silvaroli et al. (2021)