› 7k23

Electron Microscopy
3.3Å resolution

Murine polyomavirus hexavalent capsomer with 8A7H5 Fab, subparticle reconstruction

Released:
DOI: 10.2210/pdb7k23/pdb
PDB entry 7k23 coloured by chain, front view.
PDB entry 7k23 coloured by chain, side view.
PDB entry 7k23 coloured by chain, top view.
Source organisms:
Primary publication:
Antibody escape by polyomavirus capsid mutation facilitates neurovirulence.
Lauver MD, Goetschius DJ, Netherby-Winslow CS, Ayers KN, Jin G, Haas DG, Frost EL, Cho SH, Bator CM, Bywaters SM, Christensen ND, Hafenstein SL, Lukacher AE
OpenAccess logo Elife 9 (2020)
PMID: 32940605
Related structures: EMD-22641

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero pentadecamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-496369 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
8A7H5 Fab light chain Chains: L2, L3, L4, L5, L6
Molecule details ›
Chains: L2, L3, L4, L5, L6
Length: 109 amino acids
Theoretical weight: 12.09 KDa
Source organism: Rattus norvegicus
8A7H5 Fab heavy chain Chains: H2, H3, H4, H5, H6
Molecule details ›
Chains: H2, H3, H4, H5, H6
Length: 117 amino acids
Theoretical weight: 13.22 KDa
Source organism: Rattus norvegicus
Capsid protein VP1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 383 amino acids
Theoretical weight: 42.49 KDa
Source organism: Alphapolyomavirus muris
Expression system: Mus musculoides
UniProt:
  • Canonical: A0A247D727 (Residues: 2-384; Coverage: 100%)
Sequence domains: Polyomavirus coat protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-22641
Expression system: Mus musculoides

Quick links

Citations

3 review citations

JCPyV VP1 Mutations in Progressive MultifocalLeukoencephalopathy: Altering Tropismor Mediating Immune Evasion?
Lauver et al. (2020)
2 more

1 mention without citation

Antibody escape by polyomavirus capsid mutation facilitates neurovirulence.
Lauver et al. (2020)