Function and Biology

Bst DNA polymerase I time-resolved structure, 8 min post dATP addition

Source organisms:
Biochemical function: metal ion binding
Biological process: DNA biosynthetic process
Cellular component: not assigned

EC 2.7.7.7: DNA-directed DNA polymerase

Reaction catalysed:
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)
Systematic name:
Deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed)
Alternative Name(s):
  • DNA duplicase
  • DNA nucleotidyltransferase
  • DNA nucleotidyltransferase (DNA-directed)
  • DNA polymerase
  • DNA polymerase I
  • DNA polymerase II
  • DNA polymerase III
  • DNA polymerase alpha
  • DNA polymerase beta
  • DNA polymerase gamma
  • DNA replicase
  • DNA-dependent DNA polymerase
  • Deoxynucleate polymerase
  • Deoxyribonucleate nucleotidyltransferase
  • Deoxyribonucleic acid duplicase
  • Deoxyribonucleic acid polymerase
  • Deoxyribonucleic duplicase
  • Deoxyribonucleic polymerase
  • Deoxyribonucleic polymerase I
  • Duplicase
  • Klenow fragment
  • Sequenase
  • Taq DNA polymerase
  • Taq Pol I
  • Tca DNA polymerase

Sequence families

Pfam Protein families (Pfam)
PF00476
Domain description: DNA polymerase family A
Occurring in:
  1. DNA polymerase I
The deposited structure of PDB entry 7k5q contains 1 copy of Pfam domain PF00476 (DNA polymerase family A) in DNA polymerase I. Showing 1 copy in chain C [auth A].

PF22619
Domain description: DNA polymerase I, ribonuclease H-like domain
Occurring in:
  1. DNA polymerase I

InterPro InterPro annotations
IPR002298
Domain description: DNA polymerase A
Occurring in:
  1. DNA polymerase I
IPR001098
Domain description: DNA-directed DNA polymerase, family A, palm domain
Occurring in:
  1. DNA polymerase I
IPR019760
Domain description: DNA-directed DNA polymerase, family A, conserved site
Occurring in:
  1. DNA polymerase I
IPR043502
Domain description: DNA/RNA polymerase superfamily
Occurring in:
  1. DNA polymerase I
IPR018320
Domain description: DNA polymerase 1
Occurring in:
  1. DNA polymerase I
IPR012337
Domain description: Ribonuclease H-like superfamily
Occurring in:
  1. DNA polymerase I
IPR002562
Domain description: 3'-5' exonuclease domain
Occurring in:
  1. DNA polymerase I
IPR036397
Domain description: Ribonuclease H superfamily
Occurring in:
  1. DNA polymerase I