› 7k7k

Electron Microscopy
3.56Å resolution

Structure of the EPEC type III secretion injectisome EspA filament

Released:
DOI: 10.2210/pdb7k7k/pdb
PDB entry 7k7k coloured by chain, front view.
PDB entry 7k7k coloured by chain, side view.
PDB entry 7k7k coloured by chain, top view.
Source organism: Escherichia coli O127:H6 str. E2348/69
Primary publication:
Cryo-EM structure of the EspA filament from enteropathogenic Escherichia coli: Revealing the mechanism of effector translocation in the T3SS.
Lyons BJE, Atkinson CE, Deng W, Serapio-Palacios A, Finlay BB, Strynadka NCJ
Structure 29 479-487.e4 (2021)
PMID: 33453150
Related structures: EMD-22701

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo 28-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-110619 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Translocon EspA Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b
Molecule details ›
Chains: A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X, Y, Z, a, b
Length: 192 amino acids
Theoretical weight: 20.48 KDa
Source organism: Escherichia coli O127:H6 str. E2348/69
UniProt:
  • Canonical: B7UM94 (Residues: 1-192; Coverage: 100%)
Gene names: E2348C_3936, espA
Sequence domains: EspA-like secreted protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.56Å
Relevant EMDB volumes: EMD-22701

Quick links

Citations

3 review citations

Virulence-associated type III secretion systems in Gram-negative bacteria.
Pais et al. (2023)
2 more

1 mention without citation

Targeting SARS-CoV-2 Proteases for COVID-19 Antiviral Development.
Lv et al. (2021)