› 7k8c

Electron Microscopy
4.27Å resolution

CryoEM structure of a trehalose monomycolate transporter in lipid nanodiscs

Released:
DOI: 10.2210/pdb7k8c/pdb
PDB entry 7k8c coloured by chain, front view.
PDB entry 7k8c coloured by chain, side view.
PDB entry 7k8c coloured by chain, top view.
Source organism: Mycolicibacterium smegmatis MC2 155
Primary publication:
Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport.
Su CC, Klenotic PA, Cui M, Lyu M, Morgan CE, Yu EW
OpenAccess logo PLoS Biol 19 e3001370 (2021)
PMID: 34383749
Related structures: EMD-22726

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-106221 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Trehalose monomycolate exporter MmpL3 Chain: A
Molecule details ›
Chain: A
Length: 1013 amino acids
Theoretical weight: 109.51 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Escherichia coli
UniProt:
  • Canonical: A0QP27 (Residues: 1-1013; Coverage: 100%)
Gene names: MSMEG_0250, MSMEI_0243, mmpL3
Sequence domains: MMPL family

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.27Å
Relevant EMDB volumes: EMD-22726
Expression system: Escherichia coli

Quick links

Citations

6 review citations

MmpL3 Inhibition as a Promising Approach to Develop Novel Therapies against Tuberculosis: A Spotlight on SQ109, Clinical Studies, and Patents Literature.
Imran et al. (2022)
5 more

1 mention without citation

Structures of the mycobacterial membrane protein MmpL3 reveal its mechanism of lipid transport.
Su et al. (2021)