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CryoEM structure of a trehalose monomycolate transporter in lipid nanodiscs

Electron Microscopy
4.27Å resolution
PDB entry 7k8c coloured by chain, front view.
PDB entry 7k8c coloured by chain, side view.
PDB entry 7k8c coloured by chain, top view.
Source organism: Mycolicibacterium smegmatis MC2 155
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Trehalose monomycolate exporter MmpL3
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Multimeric state: monomeric
Accessible surface area: 38729.9 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-106221

Macromolecules

Trehalose monomycolate exporter MmpL3
Chain: A
Length: 1013 amino acids
Theoretical weight: 109.51 KDa
Source organism: Mycolicibacterium smegmatis MC2 155
Expression system: Escherichia coli
UniProt:
  • Canonical: A0QP27 (Residues: 1-1013; Coverage: 100%)
Gene names: MSMEG_0250, MSMEI_0243, mmpL3
Pfam: MMPL family
InterPro: Membrane transport protein MMPL domain
Trehalose monomycolate exporter MmpL3 in PDB entry 7k8c, assembly 1, front view.
Trehalose monomycolate exporter MmpL3 in PDB entry 7k8c, assembly 1, side view.
Trehalose monomycolate exporter MmpL3 in PDB entry 7k8c, assembly 1, top view.
PDBe-KB: UniProt Coverage View: A0QP27  
110131002003004005006007008009001,000
 
5001000
UniProt
A0QP27
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Secondary structure
Flexibility predictions
Sequence conservation
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