7k9h

Electron Microscopy
3.2Å resolution

SARS-CoV-2 Spike in complex with neutralizing Fab 2B04 (one up, two down conformation)

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero heptamer (preferred)
PDBe Complex ID:
PDB-CPX-210195 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (7 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1256 amino acids
Theoretical weight: 139.32 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1213; Coverage: 95%)
Gene names: 2, S
Sequence domains:
2B04 heavy chain Chains: H, I
Molecule details ›
Chains: H, I
Length: 119 amino acids
Theoretical weight: 13.16 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
2B04 light chain Chains: L, M
Molecule details ›
Chains: L, M
Length: 109 amino acids
Theoretical weight: 11.53 KDa
Source organism: Mus musculus
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, FUC
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.2Å
Relevant EMDB volumes: EMD-22748
Expression system: Homo sapiens