7kcm

Electron Microscopy
3.43Å resolution

Full-length human mitochondrial Hsp90 (TRAP1) in complex with SdhB in the presence of AMP-PNP

Released:
Source organism: Homo sapiens
Entry authors: Liu YX, Agard DA
Related structures: EMD-22816

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-149473 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Heat shock protein 75 kDa, mitochondrial Chains: A, B
Molecule details ›
Chains: A, B
Length: 651 amino acids
Theoretical weight: 74.18 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q12931 (Residues: 60-704; Coverage: 92%)
Gene names: HSP75, HSPC5, TRAP1
Sequence domains: Hsp90 protein
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial Chain: C
Molecule details ›
Chain: C
Length: 134 amino acids
Theoretical weight: 15.1 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P21912 (Residues: 29-160; Coverage: 47%)
Gene names: SDH, SDH1, SDHB
Sequence domains: 2Fe-2S iron-sulfur cluster binding domain

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.43Å
Relevant EMDB volumes: EMD-22816
Expression system: Escherichia coli