› 7kdp

Electron Microscopy
3.6Å resolution

HCMV prefusion gB in complex with fusion inhibitor WAY-174865

Released:
DOI: 10.2210/pdb7kdp/pdb
PDB entry 7kdp coloured by chain, front view.
PDB entry 7kdp coloured by chain, side view.
PDB entry 7kdp coloured by chain, top view.
Source organism: Human herpesvirus 5 strain Towne
Primary publication:
Prefusion structure of human cytomegalovirus glycoprotein B and structural basis for membrane fusion.
Liu Y, Heim KP, Che Y, Chi X, Qiu X, Han S, Dormitzer PR, Yang X
OpenAccess logo Sci Adv 7 (2021)
PMID: 33674318
Related structures: EMD-22828

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146502 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Envelope glycoprotein B Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 907 amino acids
Theoretical weight: 102.07 KDa
Source organism: Human herpesvirus 5 strain Towne
UniProt:
  • Canonical: P13201 (Residues: 1-907; Coverage: 100%)
Gene names: UL55, gB
Sequence domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 30 x NAG
Ligand WCY 3 x WCY
Ligand CA 1 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-22828

Quick links

Citations

4 review citations

Herpesvirus Nuclear Egress across the Outer Nuclear Membrane.
Roller et al. (2021)
3 more

10 mentions without citation

A widespread viral entry mechanism: The C-end Rule motif-neuropilin receptor interaction.
Balistreri et al. (2021)
9 more