› 7kgp

X-ray diffraction
1.4Å resolution

Crystal Structure of HLA-A*0201 in complex with SARS-CoV-2 N316-324

Released:
DOI: 10.2210/pdb7kgp/pdb
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PDB entry 7kgp coloured by chain, front view.
PDB entry 7kgp coloured by chain, side view.
PDB entry 7kgp coloured by chain, top view.
Source organisms:
Primary publication:
The presentation of SARS-CoV-2 peptides by the common HLA-A∗02:01 molecule.
Szeto C, Chatzileontiadou DSM, Nguyen AT, Sloane H, Lobos CA, Jayasinghe D, Halim H, Smith C, Riboldi-Tunnicliffe A, Grant EJ, Gras S
OpenAccess logo iScience 24 102096 (2021)
PMID: 33521593

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-145000 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 278 amino acids
Theoretical weight: 32.15 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q861F7 (Residues: 1-278; Coverage: 82%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 99 amino acids
Theoretical weight: 11.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Nucleoprotein Chain: C

Ligands and Environments

3 bound ligands:
Ligand ACT 1 x ACT
Ligand CD 2 x CD
Ligand NA 4 x NA
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: AUSTRALIAN SYNCHROTRON BEAMLINE MX2
Spacegroup: P212121
Unit cell:
a: 60.192Å b: 79.546Å c: 111.578Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.195 0.194 0.204
Expression systems:
  • Escherichia coli
  • Not provided

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Citations

3 review citations

The pockets guide to HLA class I molecules.
Nguyen et al. (2021)
2 more

2 mentions without citation

Seeing the T cell Immunity of SARS-CoV-2 and SARS-CoV: Believing the Epitope-Oriented Vaccines.
Yue et al. (2023)
1 more

PDB-REDO

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