› › Function and Biology

Ternary complex of VHL/BRD4-BD1/Compound9 (4-(3,5-difluoropyridin-2-yl)-N-(11-(((S)-1-((2S,4R)-4-hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-11-oxoundecyl)-10-methyl-7-((methylsulfonyl)methyl)-11-oxo-3,4,10,11-tetrahydro-1H-1,4,10-triazadibenzo[cd,f]azulene-6-carboxamide)

Source organism: Homo sapiens
Biochemical function: ubiquitin protein ligase binding
Biological process: ubiquitin-dependent protein catabolic process
Cellular component: elongin complex

Quick links

GO terms

Sequence families

Pfam Protein families (Pfam)
PF00439
Domain description: Bromodomain
Occurring in:
  1. Bromodomain-containing protein 4
The deposited structure of PDB entry 7khh contains 1 copy of Pfam domain PF00439 (Bromodomain) in Bromodomain-containing protein 4. Showing 1 copy in chain D.

PF17211
Domain description: VHL box domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
The deposited structure of PDB entry 7khh contains 1 copy of Pfam domain PF17211 (VHL box domain) in von Hippel-Lindau disease tumor suppressor. Showing 1 copy in chain C.

PF01847
Domain description: VHL beta domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
The deposited structure of PDB entry 7khh contains 1 copy of Pfam domain PF01847 (VHL beta domain) in von Hippel-Lindau disease tumor suppressor. Showing 1 copy in chain C.

PF03931
Domain description: Skp1 family, tetramerisation domain
Occurring in:
  1. Elongin-C
The deposited structure of PDB entry 7khh contains 1 copy of Pfam domain PF03931 (Skp1 family, tetramerisation domain) in Elongin-C. Showing 1 copy in chain B.

PF00240
Domain description: Ubiquitin family
Occurring in:
  1. Elongin-B
The deposited structure of PDB entry 7khh contains 1 copy of Pfam domain PF00240 (Ubiquitin family) in Elongin-B. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001487
Domain description: Bromodomain
Occurring in:
  1. Bromodomain-containing protein 4
IPR000626
Domain description: Ubiquitin-like domain
Occurring in:
  1. Elongin-B
IPR036427
Domain description: Bromodomain-like superfamily
Occurring in:
  1. Bromodomain-containing protein 4
IPR011333
Domain description: SKP1/BTB/POZ domain superfamily
Occurring in:
  1. Elongin-C
IPR018359
Domain description: Bromodomain, conserved site
Occurring in:
  1. Bromodomain-containing protein 4
IPR043508
Domain description: Brdt, bromodomain, repeat I
Occurring in:
  1. Bromodomain-containing protein 4
IPR024048
Domain description: von Hippel-Lindau disease tumour suppressor, alpha domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
IPR037139
Domain description: von Hippel-Lindau disease tumour suppressor, alpha domain superfamily
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
IPR037140
Domain description: von Hippel-Lindau disease tumour suppressor, beta domain superfamily
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
IPR022772
Domain description: von Hippel-Lindau disease tumour suppressor, beta/alpha domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
IPR024053
Domain description: von Hippel-Lindau disease tumour suppressor, beta domain
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
IPR036208
Domain description: VHL superfamily
Occurring in:
  1. von Hippel-Lindau disease tumor suppressor
IPR016073
Domain description: SKP1 component, POZ domain
Occurring in:
  1. Elongin-C
IPR039948
Domain description: Elongin-C
Occurring in:
  1. Elongin-C
IPR001232
Domain description: S-phase kinase-associated protein 1-like
Occurring in:
  1. Elongin-C
IPR039049
Domain description: Elongin B
Occurring in:
  1. Elongin-B
IPR029071
Domain description: Ubiquitin-like domain superfamily
Occurring in:
  1. Elongin-B

Quick links