Function and Biology Details
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- WD40 repeat
- Guanine nucleotide binding protein (G-protein), alpha subunit
- GPCR, family 2, secretin-like
- GPCR, family 2, glucagon-like peptide-1 receptor
- G-protein alpha subunit, group S
- G-protein, gamma subunit
- G-protein, beta subunit
- GPCR, family 2, extracellular hormone receptor domain
21 more domains
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-524901 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Molecule details ›
Chain: A
Length: 394 amino acids
Theoretical weight: 45.7 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: G-protein alpha subunit
Length: 394 amino acids
Theoretical weight: 45.7 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical:
P63092 (Residues: 1-394; Coverage: 100%)
Sequence domains: G-protein alpha subunit
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Molecule details ›
Chain: B
Length: 340 amino acids
Theoretical weight: 37.41 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: WD domain, G-beta repeat
Length: 340 amino acids
Theoretical weight: 37.41 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Molecule details ›
Chain: G
Length: 58 amino acids
Theoretical weight: 6.38 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains: GGL domain
Length: 58 amino acids
Theoretical weight: 6.38 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: P59768 (Residues: 5-62; Coverage: 82%)
Sequence domains: GGL domain
Glucagon-like peptide 1(7-37)
Molecule details ›
Chain: P
Length: 31 amino acids
Theoretical weight: 3.4 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
Sequence domains: Peptide hormone
Length: 31 amino acids
Theoretical weight: 3.4 KDa
Source organism: synthetic construct
Expression system: Not provided
UniProt:
- Canonical: P01275 (Residues: 98-128; Coverage: 19%)
Sequence domains: Peptide hormone
Glucagon-like peptide 1 receptor
Molecule details ›
Chain: R
Length: 491 amino acids
Theoretical weight: 56.75 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
Sequence domains:
Length: 491 amino acids
Theoretical weight: 56.75 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
- Canonical: P43220 (Residues: 24-463; Coverage: 100%)
Sequence domains:
