› 7kjp

Electron Microscopy
3.86Å resolution

Disulfide Stabilized Norovirus GI.1 VLP Shell Region

Released:
DOI: 10.2210/pdb7kjp/pdb
PDB entry 7kjp coloured by chain, front view.
PDB entry 7kjp coloured by chain, side view.
PDB entry 7kjp coloured by chain, top view.
Source organism: Norovirus Hu/1968/US
Primary publication:
Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes.
Verardi R, Lindesmith LC, Tsybovsky Y, Gorman J, Chuang GY, Edwards CE, Brewer-Jensen PD, Mallory ML, Ou L, Schön A, Shi W, Tully ES, Georgiou G, Baric RS, Kwong PD
OpenAccess logo NPJ Vaccines 5 110 (2020)
PMID: 33318483
Related structures: EMD-22897

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo 180-mer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182860 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Capsid protein VP1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 530 amino acids
Theoretical weight: 56.66 KDa
Source organism: Norovirus Hu/1968/US
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q83884 (Residues: 1-530; Coverage: 100%)
Gene name: ORF2
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.86Å
Relevant EMDB volumes: EMD-22897
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Self-Assembling Protein Nanoparticles in the Design of Vaccines: 2022 Update.
Morales-Hernández et al. (2022)
2 other articles

1 mention without citation

Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes.
Verardi et al. (2020)