› 7kk7

X-ray diffraction
2.8Å resolution

crystal structure of ligand-free PLEKHA7 PH domain

Released:
DOI: 10.2210/pdb7kk7/pdb
PDB entry 7kk7 coloured by chain, front view.
PDB entry 7kk7 coloured by chain, side view.
PDB entry 7kk7 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids.
Aleshin AE, Yao Y, Iftikhar A, Bobkov AA, Yu J, Cadwell G, Klein MG, Dong C, Bankston LA, Liddington RC, Im W, Powis G, Marassi FM
Structure 29 1029-1039.e3 (2021)
PMID: 33878292

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179772 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pleckstrin homology domain-containing family A member 7 Chains: A, B
Molecule details ›
Chains: A, B
Length: 127 amino acids
Theoretical weight: 14.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q6IQ23 (Residues: 164-285; Coverage: 11%)
Gene name: PLEKHA7
Sequence domains: PH domain

Ligands and Environments

2 bound ligands:
Ligand GOL 3 x GOL
Ligand EDO 1 x EDO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P212121
Unit cell:
a: 57.31Å b: 59.06Å c: 78.47Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.217 0.213 0.276
Expression system: Escherichia coli

Quick links

Citations

1 review citation

CHARMM-GUI Membrane Builder: Past, Current, and Future Developments and Applications.
Feng et al. (2023)
8 other articles

1 mention without citation

Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids.
Aleshin et al. (2021)