› 7kna

Electron Microscopy
3.3Å resolution

Localized reconstruction of the H1 A/Michigan/45/2015 ectodomain displayed at the surface of I53_dn5 nanoparticle

Released:
DOI: 10.2210/pdb7kna/pdb
PDB entry 7kna coloured by chain, front view.
PDB entry 7kna coloured by chain, side view.
PDB entry 7kna coloured by chain, top view.
Source organism: synthetic construct
Primary publication:
Quadrivalent influenza nanoparticle vaccines induce broad protection.
Boyoglu-Barnum S, Ellis D, Gillespie RA, Hutchinson GB, Park YJ, Moin SM, Acton OJ, Ravichandran R, Murphy M, Pettie D, Matheson N, Carter L, Creanga A, Watson MJ, Kephart S, Ataca S, Vaile JR, Ueda G, Crank MC, Stewart L, Lee KK, Guttman M, Baker D, Mascola JR, Veesler D, Graham BS, King NP, Kanekiyo M
OpenAccess logo Nature 592 623-628 (2021)
PMID: 33762730
Related structures: EMD-22937

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-103496 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Hemagglutinin Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 636 amino acids
Theoretical weight: 72.35 KDa
Source organism: synthetic construct
Expression system: Homo sapiens
UniProt:
  • Canonical: A0A1J0CXU0 (Residues: 18-531; Coverage: 91%)
Gene name: HA
Sequence domains: Haemagglutinin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 12 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.3Å
Relevant EMDB volumes: EMD-22937
Expression system: Homo sapiens

Quick links

Citations

38 review citations

Antibodies to combat viral infections: development strategies and progress.
Pantaleo et al. (2022)
37 more

1 mention without citation

Quadrivalent influenza nanoparticle vaccines induce broad protection.
Boyoglu-Barnum et al. (2021)