7kqh

X-ray diffraction
3.5Å resolution

Antibodies that engage the hemagglutinin receptor-binding site of influenza B viruses

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-207458 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Hemagglutinin Chains: A, B
Molecule details ›
Chains: A, B
Length: 299 amino acids
Theoretical weight: 32.67 KDa
Source organism: Influenza B virus
Expression system: Trichoplusia ni
UniProt:
  • Canonical: A0A4P8YRB6 (Residues: 46-344; Coverage: 51%)
Gene name: HA
Sequence domains: Haemagglutinin
2365 Fab heavy chain Chains: C, H
Molecule details ›
Chains: C, H
Length: 240 amino acids
Theoretical weight: 25.88 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
2365 Fab light chain Chains: D, L
Molecule details ›
Chains: D, L
Length: 216 amino acids
Theoretical weight: 23.62 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer : NEW Components: NAG, BMA, MAN
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P31
Unit cell:
a: 132.66Å b: 132.66Å c: 93.13Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.255 0.252 0.3
Expression systems:
  • Trichoplusia ni
  • Homo sapiens