› 7kqi

X-ray diffraction
4.2Å resolution

Antibodies that engage the hemagglutinin receptor-binding site of influenza B viruses

Released:
DOI: 10.2210/pdb7kqi/pdb
PDB entry 7kqi coloured by chain, front view.
PDB entry 7kqi coloured by chain, side view.
PDB entry 7kqi coloured by chain, top view.
Source organisms:
Primary publication:
Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses.
Bajic G, Harrison SC
ACS Infect Dis 7 1-5 (2021)
PMID: 33274930

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-210748 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
1209 Fab heavy chain Chain: A
Molecule details ›
Chain: A
Length: 240 amino acids
Theoretical weight: 25.96 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
1209 Fab light chain Chain: C
Molecule details ›
Chain: C
Length: 216 amino acids
Theoretical weight: 23.55 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Hemagglutinin HA1 chain Chain: B
Molecule details ›
Chain: B
Length: 298 amino acids
Theoretical weight: 32.58 KDa
Source organism: Influenza B virus (B/Yamagata/16/1988)
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P18880 (Residues: 31-328; Coverage: 86%)
Gene name: HA
Sequence domains: Haemagglutinin

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 24-ID-C
Spacegroup: P6122
Unit cell:
a: 128.1Å b: 128.1Å c: 235.28Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.377 0.372 0.42
Expression systems:
  • Homo sapiens
  • Trichoplusia ni

Quick links

Citations

5 citation in other articles

A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants.
Schmitz et al. (2021)
4 more

1 mention without citation

Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses.
Bajic et al. (2021)