› 7krb

Solution NMR

Solution Structure of the Dysferlin C2A Domain in its Calcium-bound State

Released:
DOI: 10.2210/pdb7krb/pdb
PDB entry 7krb coloured by chain, ensemble of 20 models, front view.
PDB entry 7krb coloured by chain, ensemble of 20 models, side view.
PDB entry 7krb coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Calcium binds and rigidifies the dysferlin C2A domain in a tightly coupled manner.
Wang Y, Tadayon R, Santamaria L, Mercier P, Forristal CJ, Shaw GS
Biochem J 478 197-215 (2021)
PMID: 33449082

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-131173 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dysferlin Chain: A
Molecule details ›
Chain: A
Length: 138 amino acids
Theoretical weight: 14.82 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O75923 (Residues: 1-130; Coverage: 6%)
Gene names: DYSF, FER1L1
Sequence domains: C2 domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

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Citations

3 review citations

Role of calcium-sensor proteins in cell membrane repair.
Li et al. (2023)
2 more