› 7kxy

Electron Microscopy
4.4Å resolution

Cryo-EM structure of human Factor Va at 4.4 Angstrom resolution

Released:
DOI: 10.2210/pdb7kxy/pdb
PDB entry 7kxy coloured by chain, front view.
PDB entry 7kxy coloured by chain, side view.
PDB entry 7kxy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of human coagulation factors V and Va.
Ruben EA, Rau MJ, Fitzpatrick JAJ, Di Cera E
Blood 137 3137-3144 (2021)
PMID: 33684942
Related structures: EMD-23067

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-146104 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Coagulation factor V heavy chain Chain: A
Molecule details ›
Chain: A
Length: 709 amino acids
Theoretical weight: 81.27 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P12259 (Residues: 29-737; Coverage: 32%)
Gene name: F5
Sequence domains: Multicopper oxidase
Coagulation factor V light chain Chain: B
Molecule details ›
Chain: B
Length: 651 amino acids
Theoretical weight: 75.28 KDa
Source organism: Homo sapiens
UniProt:
  • Canonical: P12259 (Residues: 1574-2224; Coverage: 30%)
Gene name: F5
Sequence domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 4.4Å
Relevant EMDB volumes: EMD-23067

Quick links

Citations

2 review citations

The Vascular Endothelium and Coagulation: Homeostasis, Disease, and Treatment, with a Focus on the Von Willebrand Factor and Factors VIII and V.
De Pablo-Moreno et al. (2022)
1 more

5 mentions without citation

Cryo-EM structures of coagulation factors.
Di Cera et al. (2022)
4 more