7kzp

Electron Microscopy
3.1Å resolution

Structure of the human Fanconi anaemia Core complex

Released:
Source organism: Homo sapiens
Primary publication:
Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.
Nat Struct Mol Biol 28 300-309 (2021)
PMID: 33686268
Related structures: EMD-23085

Function and Biology Details

Reaction catalysed:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero tetradecamer (preferred)
PDBe Complex ID:
PDB-CPX-127407 (preferred)
Entry contents:
9 distinct polypeptide molecules
Macromolecules (9 distinct):
Fanconi anemia group A protein Chains: A, S
Molecule details ›
Chains: A, S
Length: 1477 amino acids
Theoretical weight: 165.51 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fanconi anemia group B protein Chains: B, O
Molecule details ›
Chains: B, O
Length: 884 amino acids
Theoretical weight: 100.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
Fanconi anemia group C protein Chain: C
Fanconi anemia group E protein Chain: E
Fanconi anemia group F protein Chain: F
Fanconi anemia group G protein Chains: G, H
E3 ubiquitin-protein ligase FANCL Chains: L, M
Fanconi anemia core complex-associated protein 100 Chains: P, Q
Fanconi anemia core complex-associated protein 20 Chain: W

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.1Å
Relevant EMDB volumes: EMD-23085
Expression system: Homo sapiens