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Human Methionine Adenosyltransferase 2A bound to Methylthioadenosine and inhibitor, di-imido triphosphate (PNPNP)

X-ray diffraction
1.25Å resolution
PDB entry 7l1a coloured by chain, front view.
PDB entry 7l1a coloured by chain, side view.
PDB entry 7l1a coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
homo dimer (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: S-adenosylmethionine synthase isoform type-2
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Multimeric state: homo dimer
Accessible surface area: 24412.43 Å2
Buried surface area: 10077.42 Å2
Dissociation area: 3,469.78 Å2
Dissociation energy (ΔGdiss): 35.43 kcal/mol
Dissociation entropy (TΔSdiss): 14.97 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-151916

Macromolecules

S-adenosylmethionine synthase isoform type-2
Chain: A
Length: 417 amino acids
Theoretical weight: 46.28 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P31153 (Residues: 1-395; Coverage: 100%)
Gene names: AMS2, MAT2A, MATA2
Pfam:
InterPro:
S-adenosylmethionine synthase isoform type-2 in PDB entry 7l1a, assembly 1, front view.
S-adenosylmethionine synthase isoform type-2 in PDB entry 7l1a, assembly 1, side view.
S-adenosylmethionine synthase isoform type-2 in PDB entry 7l1a, assembly 1, top view.
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