› 7l1v

Electron Microscopy
3Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-208088 (preferred)
Entry contents:
6 distinct polypeptide molecules
Macromolecules (6 distinct):
Engineered Guanine nucleotide-binding protein subunit alpha Chain: A
Molecule details ›
Chain: A
Length: 244 amino acids
Theoretical weight: 28.04 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 Chain: B
Molecule details ›
Chain: B
Length: 349 amino acids
Theoretical weight: 38.58 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P62873 (Residues: 2-340; Coverage: 100%)
Gene name: GNB1
Sequence domains: WD domain, G-beta repeat
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 Chain: C
single-chain antibody Fv fragment (svFv16) Chain: H
Orexin receptor type 2 Chain: R
Synthetic nanobody 51 (Sb51) Chain: S

Ligands and Environments

1 bound ligand:
Ligand XGD 1 x XGD
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3Å
Relevant EMDB volumes: EMD-23119
Expression systems:
  • Escherichia coli
  • Trichoplusia ni
  • Homo sapiens

Quick links

Citations

7 review citations

Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs.
Laeremans et al. (2022)
6 more

5 mentions without citation

G protein-coupled receptors in neurodegenerative diseases and psychiatric disorders.
Wong et al. (2023)
4 more