7l2f

Electron Microscopy
3.9Å resolution

Cryo-EM structure of NTD-directed neutralizing antibody 5-24 in complex with prefusion SARS-CoV-2 spike glycoprotein

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero nonamer (preferred)
PDBe Complex ID:
PDB-CPX-210212 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (5 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1288 amino acids
Theoretical weight: 142.4 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:
5-24 heavy chain Chains: G, H, I
Molecule details ›
Chains: G, H, I
Length: 236 amino acids
Theoretical weight: 25.64 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
5-24 light chain Chains: J, K, L
Molecule details ›
Chains: J, K, L
Length: 216 amino acids
Theoretical weight: 23.35 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer : NEW Components: NAG, BMA
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.9Å
Relevant EMDB volumes: EMD-23127
Expression system: Homo sapiens