7l2m

Electron Microscopy
3.84Å resolution

Cryo-EM structure of DkTx/RTX-bound full-length TRPV1

Released:
Primary publication:
Structural snapshots of TRPV1 reveal mechanism of polymodal functionality.
Cell 184 5138-5150.e12 (2021)
PMID: 34496225
Related structures: EMD-23133

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-128687 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Transient receptor potential cation channel subfamily V member 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 842 amino acids
Theoretical weight: 95.33 KDa
Source organism: Rattus norvegicus
Expression system: Homo sapiens
UniProt:
  • Canonical: O35433 (Residues: 2-838; Coverage: 100%)
Gene names: Trpv1, Vr1, Vr1l
Sequence domains:
Tau-theraphotoxin-Hs1a Chains: E, F
Molecule details ›
Chains: E, F
Length: 76 amino acids
Theoretical weight: 8.68 KDa
Source organism: Cyriopagopus schmidti
Expression system: Escherichia coli 'BL21-Gold(DE3)pLysS AG'
UniProt:
  • Canonical: P0CH43 (Residues: 1-75; Coverage: 95%)

Ligands and Environments

2 bound ligands:
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this EM entry.
Resolution: 3.84Å
Relevant EMDB volumes: EMD-23133
Expression systems:
  • Homo sapiens
  • Escherichia coli 'BL21-Gold(DE3)pLysS AG'