Function and Biology Details
Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
- RNA polymerase sigma-70
- DNA-directed RNA polymerase, insert domain superfamily
- DNA-directed RNA polymerase, RpoA/D/Rpb3-type
- RNA polymerase, RBP11-like subunit
- DNA-directed RNA polymerase, alpha subunit
- DNA-directed RNA polymerase, omega subunit
- Winged helix-like DNA-binding domain superfamily
- RNA polymerase sigma factor, region 3/4-like
38 more domains
Structure analysis Details
Assembly composition:
hetero hexamer (preferred)
PDBe Complex ID:
PDB-CPX-172668 (preferred)
Entry contents:
5 distinct polypeptide molecules
Macromolecules (5 distinct):
DNA-directed RNA polymerase subunit alpha
Molecule details ›
Chains: A, B
Length: 315 amino acids
Theoretical weight: 34.96 KDa
Source organism: Clostridia bacterium
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 315 amino acids
Theoretical weight: 34.96 KDa
Source organism: Clostridia bacterium
Expression system: Escherichia coli
UniProt:
- Canonical:
Q18CI5 (Residues: 1-315; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase subunit beta
Molecule details ›
Chain: C
Length: 1266 amino acids
Theoretical weight: 142.37 KDa
Source organism: Clostridia bacterium
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 1266 amino acids
Theoretical weight: 142.37 KDa
Source organism: Clostridia bacterium
Expression system: Escherichia coli
UniProt:
- Canonical: Q18CF1 (Residues: 2-1238; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase subunit beta'
Molecule details ›
Chain: D
Length: 1161 amino acids
Theoretical weight: 129.92 KDa
Source organism: Clostridia bacterium
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 1161 amino acids
Theoretical weight: 129.92 KDa
Source organism: Clostridia bacterium
Expression system: Escherichia coli
UniProt:
- Canonical: Q18CF3 (Residues: 1-1161; Coverage: 100%)
Sequence domains:
DNA-directed RNA polymerase subunit omega
Molecule details ›
Chain: E
Length: 88 amino acids
Theoretical weight: 10.21 KDa
Source organism: Clostridia bacterium
Expression system: Escherichia coli
UniProt:
Sequence domains: RNA polymerase Rpb6
Length: 88 amino acids
Theoretical weight: 10.21 KDa
Source organism: Clostridia bacterium
Expression system: Escherichia coli
UniProt:
- Canonical: Q182S6 (Residues: 1-88; Coverage: 100%)
Sequence domains: RNA polymerase Rpb6
RNA polymerase sigma factor SigA
Molecule details ›
Chain: F
Length: 390 amino acids
Theoretical weight: 44.48 KDa
Source organism: Clostridia bacterium
Expression system: Escherichia coli
UniProt:
Sequence domains:
Length: 390 amino acids
Theoretical weight: 44.48 KDa
Source organism: Clostridia bacterium
Expression system: Escherichia coli
UniProt:
- Canonical: Q18BX5 (Residues: 2-390; Coverage: 100%)
Sequence domains:
