› 7l96

Solution NMR

Connecting hydrophobic surfaces in cyclic peptides increases membrane permeability

Released:
DOI: 10.2210/pdb7l96/pdb
PDB entry 7l96 coloured by chain, ensemble of 5 models, front view.
PDB entry 7l96 coloured by chain, ensemble of 5 models, side view.
PDB entry 7l96 coloured by chain, ensemble of 5 models, top view.
Source organism: Homo sapiens
Primary publication:
Connecting Hydrophobic Surfaces in Cyclic Peptides Increases Membrane Permeability.
Hoang HN, Hill TA, Fairlie DP
Angew Chem Int Ed Engl 60 8385-8390 (2021)
PMID: 33185961

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-223990 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclic peptide LEU-DLE-LEU-LEU-DPR-N9K Chain: A
Molecule details ›
Chain: A
Length: 6 amino acids
Theoretical weight: 745 Da
Source organism: Homo sapiens
Expression system: Not provided

Ligands and Environments

No bound ligands
2 modified residues:
Ligand DLE 1 x DLE
Ligand DPR 1 x DPR

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 9%
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

5 review citations

Targeting intracellular protein-protein interactions with macrocyclic peptides.
Buyanova et al. (2022)
4 more