› 7l9a

X-ray diffraction
2.27Å resolution

Crystal structure of BRDT bromodomain 2 in complex with CDD-1102

Released:
DOI: 10.2210/pdb7l9a/pdb
Model geometry
Fit model/data
PDB entry 7l9a coloured by chain, front view.
PDB entry 7l9a coloured by chain, side view.
PDB entry 7l9a coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.
Yu Z, Ku AF, Anglin JL, Sharma R, Ucisik MN, Faver JC, Li F, Nyshadham P, Simmons N, Sharma KL, Nagarajan S, Riehle K, Kaur G, Sankaran B, Storl-Desmond M, Palmer SS, Young DW, Kim C, Matzuk MM
OpenAccess logo Proc Natl Acad Sci U S A 118 (2021)
PMID: 33637650

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176744 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Bromodomain testis-specific protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 135 amino acids
Theoretical weight: 15.78 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q58F21 (Residues: 269-380; Coverage: 12%)
Gene name: BRDT
Sequence domains: Bromodomain

Ligands and Environments

2 bound ligands:
Ligand XWP 2 x XWP
Ligand BME 2 x BME
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P3221
Unit cell:
a: 56.47Å b: 56.47Å c: 191.901Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.236 0.235 0.265
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

Functional Roles of Bromodomain Proteins in Cancer.
Boyson et al. (2021)
5 more

1 mention without citation

Discovery and characterization of bromodomain 2-specific inhibitors of BRDT.
Yu et al. (2021)