Function and Biology

The mature Usutu SAAR-1776, Model A

Source organism: Usutu virus
Biochemical function: protein dimerization activity
Biological process: viral life cycle
Cellular component: not assigned

EC 3.6.4.13: RNA helicase

Reaction catalysed:
ATP + H(2)O = ADP + phosphate
Systematic name:
ATP phosphohydrolase (RNA helix unwinding)
Alternative Name(s):
  • CSFV NS3 helicase
  • DBP2
  • DDX17
  • DDX25
  • DDX3
  • DDX3X
  • DDX3Y
  • DDX4
  • DDX5
  • DEAD-box RNA helicase
  • DEAD-box protein DED1
  • DEAH-box RNA helicase
  • DEAH-box protein 2
  • DED1
  • DbpA
  • Dex(H/D) RNA helicase
  • EIF4A helicase
  • EhDEAD1
  • EhDEAD1 RNA helicase
  • GRTH/DDX25
  • KOKV helicase
  • Mtr4p
  • NPH-II
  • Nonstructural protein 3 helicase
  • RHA
  • RNA helicase A
  • RNA helicase DDX3
  • RNA helicase Hera
  • RNA-dependent ATPase
  • TGBp1 NTPase/helicase domain
  • VRH1

EC 3.6.1.15: Nucleoside-triphosphate phosphatase

Reaction catalysed:
NTP + H(2)O = NDP + phosphate
Systematic name:
Unspecific diphosphate phosphohydrolase
Alternative Name(s):
  • NTPase
  • Nucleoside 5-triphosphatase
  • Nucleoside triphosphate hydrolase
  • Nucleoside triphosphate phosphohydrolase
  • Nucleoside-5-triphosphate phosphohydrolase
  • Nucleoside-triphosphatase

EC 3.4.21.91: Flavivirin

Reaction catalysed:
Selective hydrolysis of -Xaa-Xaa-|-Yaa- bonds in which each of the Xaa can be either Arg or Lys and Yaa can be either Ser or Ala.
Alternative Name(s):
  • NS2B-3 proteinase
  • Yellow fever virus (flavivirus) protease
  • Yellow fever virus protease

EC 2.7.7.48: RNA-directed RNA polymerase

Reaction catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Systematic name:
Nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)
Alternative Name(s):
  • 3D polymerase
  • PB1 proteins
  • PB2 proteins
  • Phage f2 replicase
  • Polymerase L
  • Q-beta replicase
  • RDRP
  • RNA nucleotidyltransferase (RNA-directed)
  • RNA replicase
  • RNA synthetase
  • RNA transcriptase
  • RNA-dependent RNA polymerase
  • RNA-dependent RNA replicase
  • RNA-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid replicase
  • Ribonucleic acid-dependent ribonucleate nucleotidyltransferase
  • Ribonucleic acid-dependent ribonucleic acid polymerase
  • Ribonucleic replicase
  • Ribonucleic synthetase
  • Transcriptase

EC 2.1.1.57: Methyltransferase cap1

Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleotide)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:5'-(N(7)-methyl 5'-triphosphoguanosine)-(ribonucleotide)-[mRNA] 2-O-methyltransferase
Alternative Name(s):
  • Cap1-MTase
  • MTR1
  • Messenger RNA (nucleoside-2'-)-methyltransferase
  • Messenger ribonucleate nucleoside 2'-methyltransferase
  • S-adenosyl-L-methionine:mRNA (nucleoside-2'-O)-methyltransferase
  • mRNA (nucleoside-2'-O)-methyltransferase

EC 2.1.1.56: mRNA (guanine-N(7))-methyltransferase

Reaction catalysed:
S-adenosyl-L-methionine + a 5'-(5'-triphosphoguanosine)-[mRNA] = S-adenosyl-L-homocysteine + a 5'-(N(7)-methyl 5'-triphosphoguanosine)-[mRNA]
Systematic name:
S-adenosyl-L-methionine:mRNA (guanine-N(7))-methyltransferase
Alternative Name(s):
  • Guanine-7-methyltransferase
  • Messenger RNA guanine 7-methyltransferase
  • Messenger ribonucleate guanine 7-methyltransferase
  • S-adenosyl-L-methionine:mRNA (guanine-7-N)-methyltransferase

GO terms

Biochemical function:
Biological process:
Cellular component:
  • not assigned

Sequence families

Pfam Protein families (Pfam)
PF01004
Domain description: Flavivirus envelope glycoprotein M
Occurring in:
  1. Small envelope protein M
The deposited structure of PDB entry 7lcg contains 3 copies of Pfam domain PF01004 (Flavivirus envelope glycoprotein M) in Small envelope protein M. Showing 1 copy in chain B.

PF21659
Domain description: Flavivirus envelope glycoprotein E, stem/anchor domain
Occurring in:
  1. Envelope protein E

PF02832
Domain description: Flavivirus glycoprotein, immunoglobulin-like domain
Occurring in:
  1. Envelope protein E
The deposited structure of PDB entry 7lcg contains 3 copies of Pfam domain PF02832 (Flavivirus glycoprotein, immunoglobulin-like domain) in Envelope protein E. Showing 1 copy in chain E.

PF00869
Domain description: Flavivirus glycoprotein, central and dimerisation domains
Occurring in:
  1. Envelope protein E
The deposited structure of PDB entry 7lcg contains 3 copies of Pfam domain PF00869 (Flavivirus glycoprotein, central and dimerisation domains) in Envelope protein E. Showing 1 copy in chain E.

InterPro InterPro annotations
IPR027287
Domain description: Glycoprotein E, immunoglobulin-like domain, flavivirus
Occurring in:
  1. Envelope protein E
IPR000069
Domain description: Envelope glycoprotein M, flavivirus
Occurring in:
  1. Small envelope protein M
IPR038302
Domain description: Envelope glycoprotein M superfamily, flavivirus
Occurring in:
  1. Small envelope protein M
IPR038345
Domain description: Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily
Occurring in:
  1. Envelope protein E
IPR026470
Domain description: Flavivirus envelope glycoprotein E, Stem/Anchor domain
Occurring in:
  1. Envelope protein E
IPR000336
Domain description: Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily
Occurring in:
  1. Envelope protein E
IPR014756
Domain description: Immunoglobulin E-set
Occurring in:
  1. Envelope protein E
IPR013755
Domain description: Flaviviral glycoprotein E, central domain, subdomain 1
Occurring in:
  1. Envelope protein E
IPR013756
Domain description: Flaviviral glycoprotein E, central domain, subdomain 2
Occurring in:
  1. Envelope protein E
IPR038055
Domain description: Flaviviral glycoprotein E, dimerisation domain
Occurring in:
  1. Envelope protein E
IPR011998
Domain description: Envelope glycoprotein E, central and dimerisation domain, flavivirus
Occurring in:
  1. Envelope protein E
IPR036253
Domain description: Flavivirus glycoprotein, central and dimerisation domain superfamily
Occurring in:
  1. Envelope protein E