› 7lfy

Electron Microscopy
3.6Å resolution

Cryo-EM structure of human cGMP-bound open CNGA1 channel in Na+

Released:
DOI: 10.2210/pdb7lfy/pdb
PDB entry 7lfy coloured by chain, front view.
PDB entry 7lfy coloured by chain, side view.
PDB entry 7lfy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural mechanisms of gating and selectivity of human rod CNGA1 channel.
Xue J, Han Y, Zeng W, Wang Y, Jiang Y
Neuron 109 1302-1313.e4 (2021)
PMID: 33651975
Related structures: EMD-23309

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151593 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclic nucleotide-gated channel alpha-1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 560 amino acids
Theoretical weight: 64.65 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P29973 (Residues: 140-686; Coverage: 80%)
Gene names: CNCG, CNCG1, CNGA1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand PCG 4 x PCG
Ligand NA 3 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.6Å
Relevant EMDB volumes: EMD-23309
Expression system: Homo sapiens

Quick links

Citations

3 review citations

Biology, Pathobiology and Gene Therapy of CNG Channel-Related Retinopathies.
Gerhardt et al. (2023)
2 more

3 mentions without citation

Structural view of G protein-coupled receptor signaling in the retinal rod outer segment.
Gulati et al. (2023)
2 more