› 7lg0

X-ray diffraction
2.3Å resolution

Human leukocyte antigen B*07:02 in complex with SARS-CoV2 epitope SPRWYFYYL

Released:
DOI: 10.2210/pdb7lg0/pdb
PDB entry 7lg0 coloured by chain, front view.
PDB entry 7lg0 coloured by chain, side view.
PDB entry 7lg0 coloured by chain, top view.
Source organisms:
Entry authors: Patskovska L, Patskovsky Y, Krogsgaard M

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-135168 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
HLA class I histocompatibility antigen, B alpha chain Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 31.96 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P01889 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-B, HLAB
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Nucleoprotein Chain: C
Molecule details ›
Chain: C
Length: 9 amino acids
Theoretical weight: 1.3 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Not provided
UniProt:
  • Canonical: P59595 (Residues: 106-114; Coverage: 2%)
Gene names: 9a, N

Ligands and Environments

1 bound ligand:
Ligand P6G 1 x P6G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: C2221
Unit cell:
a: 71.723Å b: 155.172Å c: 88.165Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.202 0.2 0.268
Expression systems:
  • Escherichia coli BL21(DE3)
  • Escherichia coli
  • Not provided

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