› 7lhb

X-ray diffraction
2.07Å resolution

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-145305 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Apoptosis regulator Bcl-2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 166 amino acids
Theoretical weight: 19.36 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P10415 (Residues: 1-207; Coverage: 70%)
Gene name: BCL2
Sequence domains:

Ligands and Environments

1 bound ligand:
Ligand XZD 3 x XZD
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 17-ID
Spacegroup: P21
Unit cell:
a: 62.362Å b: 49.448Å c: 89.359Å
α: 90° β: 103.63° γ: 90°
R-values:
R R work R free
0.204 0.202 0.238
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Clinical experiences with venetoclax and other pro-apoptotic agents in lymphoid malignancies: lessons from monotherapy and chemotherapy combination.
Lew et al. (2022)
2 more

1 mention without citation

Potential Hepatoprotective Effects of Chamaecyparis lawsoniana against Methotrexate-Induced Liver Injury: Integrated Phytochemical Profiling, Target Network Analysis, and Experimental Validation.
Fikry et al. (2023)

PDB-REDO

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