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Metabolism of a hybrid algal galactan by members of the human gut microbiome.

Robb CS, Hobbs JK, Pluvinage B, Reintjes G, Klassen L, Monteith S, Giljan G, Amundsen C, Vickers C, Hettle AG, Hills R, Xing X, Montina T, Zandberg WF, Abbott DW, Boraston AB
Nat Chem Biol 18 501-510 (2022)
Related entries: 7lh6, 7lha, 7lj2, 7ljj, 7lnp

Cited: 11 times
EuropePMC logo PMID: 35289327

Abstract

Native porphyran is a hybrid of porphryan and agarose. As a common element of edible seaweed, this algal galactan is a frequent component of the human diet. Bacterial members of the human gut microbiota have acquired polysaccharide utilization loci (PULs) that enable the metabolism of porphyran or agarose. However, the molecular mechanisms that underlie the deconstruction and use of native porphyran remains incompletely defined. Here, we have studied two human gut bacteria, porphyranolytic Bacteroides plebeius and agarolytic Bacteroides uniformis, that target native porphyran. This reveals an exo-based cycle of porphyran depolymerization that incorporates a keystone sulfatase. In both PULs this cycle also works together with a PUL-encoded agarose depolymerizing machinery to synergistically reduce native porphyran to monosaccharides. This provides a framework for understanding the deconstruction of a hybrid algal galactan, and insight into the competitive and/or syntrophic relationship of gut microbiota members that target rare nutrients.

Articles - 7lk7 mentioned but not cited (1)

  1. Discovery of α-l-Glucosidase Raises the Possibility of α-l-Glucosides in Nature. Shishiuchi R, Kang H, Tagami T, Ueda Y, Lang W, Kimura A, Okuyama M. ACS Omega 7 47411-47423 (2022)


Reviews citing this publication (2)

  1. Sulfatases: Critical Enzymes for Algal Polysaccharide Processing. Hettle AG, Vickers CJ, Boraston AB. Front Plant Sci 13 837636 (2022)
  2. Structure and function of microbial α-l-fucosidases: a mini review. Wu H, Owen CD, Juge N. Essays Biochem 67 399-414 (2023)

Articles citing this publication (8)

  1. Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota. Luis AS, Baslé A, Byrne DP, Wright GSA, London JA, Jin C, Karlsson NG, Hansson GC, Eyers PA, Czjzek M, Barbeyron T, Yates EA, Martens EC, Cartmell A. Nat Chem Biol 18 841-849 (2022)
  2. SulfAtlas, the sulfatase database: state of the art and new developments. Stam M, Lelièvre P, Hoebeke M, Corre E, Barbeyron T, Michel G. Nucleic Acids Res 51 D647-D653 (2023)
  3. Agarolytic Pathway in the Newly Isolated Aquimarina sp. Bacterial Strain ERC-38 and Characterization of a Putative β-agarase. Kang JY, Song HY, Kim JM. Mar Biotechnol (NY) 25 314-327 (2023)
  4. Fungal β-glucan-facilitated cross-feeding activities between Bacteroides and Bifidobacterium species. Fernandez-Julia P, Black GW, Cheung W, Van Sinderen D, Munoz-Munoz J. Commun Biol 6 576 (2023)
  5. Separation and Visualization of Glycans by Fluorophore-Assisted Carbohydrate Electrophoresis. Robb M, Hobbs JK, Boraston AB. Methods Mol Biol 2657 215-222 (2023)
  6. Structural and digestive characters of a heteropolysaccharide fraction from tea (Camellia sinensis L.) flower. Chen D, Wang A, Lv J, Tang C, Jin CH, Liu J, Zeng X, Wang L. Food Chem X 21 101058 (2024)
  7. Synthesis of 2'-fucosyllactose from apple pomace-derived xyloglucan oligosaccharides by an α-L-fucosidase from Pedobacter sp. CAU209. Shi R, Yang SQ, Wang NN, Yan QJ, Yan XM, Jiang ZQ. Appl Microbiol Biotechnol 107 3579-3591 (2023)
  8. The Discovery of the Fucoidan-Active Endo-1→4-α-L-Fucanase of the GH168 Family, Which Produces Fucoidan Derivatives with Regular Sulfation and Anticoagulant Activity. Silchenko AS, Taran IV, Usoltseva RV, Zvyagintsev NV, Zueva AO, Rubtsov NK, Lembikova DE, Nedashkovskaya OI, Kusaykin MI, Isaeva MP, Ermakova SP. Int J Mol Sci 25 218 (2023)


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