› 7lkz

Electron Microscopy
3.27Å resolution

Structure of ATP-bound human ABCA4

Released:
DOI: 10.2210/pdb7lkz/pdb
PDB entry 7lkz coloured by chain, front view.
PDB entry 7lkz coloured by chain, side view.
PDB entry 7lkz coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Molecular structures of the eukaryotic retinal importer ABCA4.
Liu F, Lee J, Chen J
OpenAccess logo Elife 10 (2021)
PMID: 33605212
Related structures: EMD-23410

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160256 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Retinal-specific phospholipid-transporting ATPase ABCA4 Chain: A
Molecule details ›
Chain: A
Length: 2273 amino acids
Theoretical weight: 256.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P78363 (Residues: 1-2273; Coverage: 100%)
Gene names: ABCA4, ABCR
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
Carbohydrate polymer : NEW Components: NAG, BMA
Carbohydrate polymer
5 bound ligands:
Ligand 6OU 3 x 6OU
Ligand POV 5 x POV
Ligand NAG 6 x NAG
Ligand MG 2 x MG
Ligand ATP 2 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.27Å
Relevant EMDB volumes: EMD-23410
Expression system: Homo sapiens

Quick links

Citations

8 review citations

An Overview of the Genetics of ABCA4 Retinopathies, an Evolving Story.
Al-Khuzaei et al. (2021)
7 more

7 mentions without citation

Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease.
Scortecci et al. (2021)
6 more