7lmb

Electron Microscopy
3.8Å resolution

Tetrahymena telomerase T5D5 structure at 3.8 Angstrom

Released:
Source organism: Tetrahymena thermophila
Related structures: EMD-23439

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero octamer (preferred)
PDBe Complex ID:
PDB-CPX-494890 (preferred)
Entry contents:
6 distinct polypeptide molecules
1 distinct DNA molecule
1 distinct RNA molecule
Macromolecules (8 distinct):
La-related protein 7 homolog Chain: H
Molecule details ›
Chain: H
Length: 542 amino acids
Theoretical weight: 64.21 KDa
Source organism: Tetrahymena thermophila
UniProt:
  • Canonical: W7X6T2 (Residues: 1-542; Coverage: 100%)
Gene names: TAP65, TTHERM_000318539
Sequence domains:
Telomerase reverse transcriptase Chain: A
Molecule details ›
Chain: A
Length: 1117 amino acids
Theoretical weight: 133.49 KDa
Source organism: Tetrahymena thermophila
UniProt:
  • Canonical: O77448 (Residues: 1-1117; Coverage: 100%)
Gene names: TERT, TTHERM_00112560
Sequence domains:
Telomeric repeat-binding subunit 1 Chain: D
Molecule details ›
Chain: D
Length: 701 amino acids
Theoretical weight: 82.04 KDa
Source organism: Tetrahymena thermophila
UniProt:
  • Canonical: D2CVN6 (Residues: 1-701; Coverage: 100%)
Gene names: TAP82, TEB1, TTHERM_00218760
Sequence domains: Replication factor-A C terminal domain
Replication protein A 32 kDa subunit Chain: E
Molecule details ›
Chain: E
Length: 269 amino acids
Theoretical weight: 30.99 KDa
Source organism: Tetrahymena thermophila
UniProt:
  • Canonical: A0A0U8TRG9 (Residues: 1-269; Coverage: 100%)
Gene names: RPA2, TEB2, TTHERM_001113129
Replication protein A 14 kDa subunit Chain: F
Molecule details ›
Chain: F
Length: 121 amino acids
Theoretical weight: 14.01 KDa
Source organism: Tetrahymena thermophila
UniProt:
  • Canonical: A0A0U8UFF4 (Residues: 1-121; Coverage: 100%)
Gene names: RPA2, TEB3, TTHERM_00439320
Sequence domains: Replication factor A protein 3
Telomerase-associated protein of 50 kDa Chain: G
Molecule details ›
Chain: G
Length: 422 amino acids
Theoretical weight: 50.05 KDa
Source organism: Tetrahymena thermophila
UniProt:
  • Canonical: D2CVN8 (Residues: 1-422; Coverage: 100%)
Gene names: TAP50, TTHERM_01049190
telomere DNA Chain: C
Molecule details ›
Chain: C
Length: 21 nucleotides
Theoretical weight: 6.67 KDa
Telomerase RNA Chain: B
Molecule details ›
Chain: B
Length: 159 nucleotides
Theoretical weight: 50.75 KDa
Sequence domains: Ciliate telomerase RNA

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.8Å
Relevant EMDB volumes: EMD-23439