› 7lmt

X-ray diffraction
2.27Å resolution

Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a

Released:
DOI: 10.2210/pdb7lmt/pdb
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PDB entry 7lmt coloured by chain, front view.
PDB entry 7lmt coloured by chain, side view.
PDB entry 7lmt coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Lei M, Freitas RF, Dong A, Schapira M, Arrowsmith CH, Edwards AM, Min J, Structural Genomics Consortium (SGC)

Function and Biology Details

Reaction catalysed: 
(1a) S-adenosyl-L-methionine + a [histone H3]-L-lysine(36) = S-adenosyl-L-homocysteine + a [histone H3]-N(6)-methyl-L-lysine(36)
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
homo octamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132138 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase NSD2 Chains: A, B, C, D, E, F, G, H
Molecule details ›
Chains: A, B, C, D, E, F, G, H
Length: 140 amino acids
Theoretical weight: 16.01 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O96028 (Residues: 211-350; Coverage: 10%)
Gene names: KIAA1090, MMSET, NSD2, TRX5, WHSC1
Sequence domains: PWWP domain

Ligands and Environments

2 bound ligands:
Ligand Y6V 8 x Y6V
Ligand UNX 2 x UNX
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P1
Unit cell:
a: 68.3Å b: 69.1Å c: 80.192Å
α: 75.52° β: 79.36° γ: 60.47°
R-values:
R R work R free
0.221 0.218 0.26
Expression system: Escherichia coli BL21(DE3)

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