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Cryo-EM structure of neutralizing antibody 1-57 in complex with prefusion SARS-CoV-2 spike glycoprotein

Source organisms:
Biochemical function: not assigned
Biological process: endocytosis involved in viral entry into host cell
Cellular component: virion membrane

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF01601
Domain description: Coronavirus spike glycoprotein S2
Occurring in:
  1. Spike glycoprotein
The deposited structure of PDB entry 7ls9 contains 3 copies of Pfam domain PF01601 (Coronavirus spike glycoprotein S2) in Spike glycoprotein. Showing 1 copy in chain A.

PF19209
Domain description: Coronavirus spike glycoprotein S1, C-terminal
Occurring in:
  1. Spike glycoprotein
The deposited structure of PDB entry 7ls9 contains 3 copies of Pfam domain PF19209 (Coronavirus spike glycoprotein S1, C-terminal) in Spike glycoprotein. Showing 1 copy in chain A.

PF09408
Domain description: Betacoronavirus spike glycoprotein S1, receptor binding
Occurring in:
  1. Spike glycoprotein
The deposited structure of PDB entry 7ls9 contains 3 copies of Pfam domain PF09408 (Betacoronavirus spike glycoprotein S1, receptor binding) in Spike glycoprotein. Showing 1 copy in chain A.

PF16451
Domain description: Betacoronavirus-like spike glycoprotein S1, N-terminal
Occurring in:
  1. Spike glycoprotein
The deposited structure of PDB entry 7ls9 contains 3 copies of Pfam domain PF16451 (Betacoronavirus-like spike glycoprotein S1, N-terminal) in Spike glycoprotein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. 1-57 Fab heavy chain
  2. 1-57 Fab light chain
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. 1-57 Fab heavy chain
  2. 1-57 Fab light chain
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. 1-57 Fab heavy chain
  2. 1-57 Fab light chain
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. 1-57 Fab heavy chain
  2. 1-57 Fab light chain
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. 1-57 Fab heavy chain
  2. 1-57 Fab light chain
IPR003599
Domain description: Immunoglobulin domain subtype
Occurring in:
  1. 1-57 Fab heavy chain
  2. 1-57 Fab light chain
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. 1-57 Fab heavy chain
  2. 1-57 Fab light chain
IPR043473
Domain description: Spike glycoprotein S2 superfamily, coronavirus
Occurring in:
  1. Spike glycoprotein
IPR018548
Domain description: Spike (S) protein S1 subunit, receptor-binding domain, betacoronavirus
Occurring in:
  1. Spike glycoprotein
IPR032500
Domain description: Spike glycoprotein S1, N-terminal domain, betacoronavirus-like
Occurring in:
  1. Spike glycoprotein
IPR012473
Domain description: Fibritin C-terminal
Occurring in:
  1. Spike glycoprotein
IPR044874
Domain description: Spike glycoprotein S2, coronavirus, heptad repeat 2
Occurring in:
  1. Spike glycoprotein
IPR044873
Domain description: Spike glycoprotein S2, coronavirus, heptad repeat 1
Occurring in:
  1. Spike glycoprotein
IPR002552
Domain description: Spike glycoprotein S2, coronavirus
Occurring in:
  1. Spike glycoprotein
IPR043607
Domain description: Coronavirus spike glycoprotein S1, C-terminal
Occurring in:
  1. Spike glycoprotein
IPR036326
Domain description: Spike S1 subunit, receptor binding domain superfamily, betacoronavirus
Occurring in:
  1. Spike glycoprotein
IPR044366
Domain description: Spike (S) protein S1 subunit, receptor-binding domain, SARS-CoV-2
Occurring in:
  1. Spike glycoprotein
IPR043002
Domain description: Spike glycoprotein, N-terminal domain superfamily
Occurring in:
  1. Spike glycoprotein
IPR044341
Domain description: Spike (S) protein S1 subunit, N-terminal domain, SARS-CoV-like
Occurring in:
  1. Spike glycoprotein
IPR042578
Domain description: Spike glycoprotein, betacoronavirus
Occurring in:
  1. Spike glycoprotein

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