› 7lw1

Electron Microscopy
2.9Å resolution

Human phosphofructokinase-1 liver type bound to activator NA-11

Released:
DOI: 10.2210/pdb7lw1/pdb
PDB entry 7lw1 coloured by chain, front view.
PDB entry 7lw1 coloured by chain, side view.
PDB entry 7lw1 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Selective activation of PFKL suppresses the phagocytic oxidative burst.
Amara N, Cooper MP, Voronkova MA, Webb BA, Lynch EM, Kollman JM, Ma T, Yu K, Lai Z, Sangaraju D, Kayagaki N, Newton K, Bogyo M, Staben ST, Dixit VM
Cell 184 4480-4494.e15 (2021)
PMID: 34320407
Related structures: EMD-23544

Function and Biology Details

Reaction catalysed: 
ATP + beta-D-fructose 6-phosphate = ADP + beta-D-fructose 1,6-bisphosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148190 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
ATP-dependent 6-phosphofructokinase, liver type Chains: A, D, E, F
Molecule details ›
Chains: A, D, E, F
Length: 780 amino acids
Theoretical weight: 85.12 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P17858 (Residues: 1-780; Coverage: 100%)
Gene name: PFKL
Sequence domains: Phosphofructokinase

Ligands and Environments

4 bound ligands:
Ligand YG1 4 x YG1
Ligand FBP 4 x FBP
Ligand F6P 4 x F6P
Ligand ADP 4 x ADP
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.9Å
Relevant EMDB volumes: EMD-23544
Expression system: unidentified baculovirus

Quick links

Citations

21 review citations

The pentose phosphate pathway in health and disease.
TeSlaa et al. (2023)
20 more

4 mentions without citation

Selective activation of PFKL suppresses the phagocytic oxidative burst.
Amara et al. (2021)
3 more