› 7lwq

Electron Microscopy
3.44Å resolution

Mink Cluster 5-associated SARS-CoV-2 spike protein(S-GSAS-D614G-delFV) missing the S1 subunit and SD2 subdomain of one protomer

Released:
DOI: 10.2210/pdb7lwq/pdb
PDB entry 7lwq coloured by chain, front view.
PDB entry 7lwq coloured by chain, side view.
PDB entry 7lwq coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.
Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Stalls V, Kopp MF, Manne K, Li D, Wiehe K, Saunders KO, Edwards RJ, Korber B, Haynes BF, Henderson R, Acharya P
OpenAccess logo Science 373 (2021)
PMID: 34168071
Related structures: EMD-23554

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1286 amino acids
Theoretical weight: 142.11 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 27 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.44Å
Relevant EMDB volumes: EMD-23554
Expression system: Homo sapiens

Quick links

Citations

37 review citations

The biological and clinical significance of emerging SARS-CoV-2 variants.
Tao et al. (2021)
36 more

1 mention without citation

Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity.
Gobeil et al. (2021)