EC 2.7.12.2: Mitogen-activated protein kinase kinase
Reaction catalysed:
ATP + L-seryl/L-threonyl/L-tyrosyl-[protein] = ADP + O-phospho-L-seryl/O-phospho-L-threonyl/O-phospho-L-tyrosyl-[protein]
Systematic name:
ATP:protein phosphotransferase (MAPKKK-activated)
Alternative Name(s):
- MAP kinase kinase
- MAP kinase kinase 4
- MAP kinase kinase 7
- MAP kinase or ERK kinase
- MAP2K
- MAPKK
- MAPKK1
- MEK
- MEK1
- MEK2
- MKK
- MKK2
- MKK4
- MKK6
- MKK7
- STK27
EC 2.7.11.1: Non-specific serine/threonine protein kinase
Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Systematic name:
ATP:protein phosphotransferase (non-specific)
Alternative Name(s):
- A-kinase
- AP50 kinase
- ATP-protein transphosphorylase
- Beta-IIPKC
- Beta-adrenergic receptor kinase
- CK-2
- CKI
- CKII
- Calcium-dependent protein kinase C
- Calcium/phospholipid-dependent protein kinase
- Casein kinase
- Casein kinase (phosphorylating)
- Casein kinase 2
- Casein kinase I
- Casein kinase II
- Cyclic AMP-dependent protein kinase
- Cyclic AMP-dependent protein kinase A
- Cyclic monophosphate-dependent protein kinase
- Cyclic nucleotide-dependent protein kinase
- Cyclin-dependent kinase
- Cytidine 3',5'-cyclic monophosphate-responsive protein kinase
- Dsk1
- Epsilon PKC
- Glycogen synthase A kinase
- Glycogen synthase a kinase
- Glycogen synthase kinase
- HIPK2
- Hpr kinase
- Hydroxyalkyl-protein kinase
- M phase-specific cdc2 kinase
- MAPK
- Mitogen-activated S6 kinase
- Mitogen-activated protein kinase
- P82 kinase
- PKA
- PKC
- Phosphorylase B kinase kinase
- Phosphorylase b kinase kinase
- Phosphorylase b kinase kinase
- Protein glutamyl kinase
- Protein kinase (phosphorylating)
- Protein kinase A
- Protein kinase CK2
- Protein kinase p58
- Protein phosphokinase
- Protein serine kinase
- Protein serine-threonine kinase
- Protein-aspartyl kinase
- Protein-cysteine kinase
- Protein-serine kinase
- Prp4 protein kinase
- Raf kinase
- Raf-1
- Ribosomal S6 protein kinase
- Ribosomal protein S6 kinase II
- STK32
- Serine kinase
- Serine protein kinase
- Serine(threonine) protein kinase
- Serine-specific protein kinase
- Serine/threonine protein kinase
- T-antigen kinase
- Threonine-specific protein kinase
- Twitchin kinase
- Type-2 casein kinase
- WEE1Hu
- Wee 1-like kinase
- Wee-kinase
- cAMP-dependent protein kinase
- cAMP-dependent protein kinase A
- cGMP-dependent protein kinase
Protein families (Pfam)![The deposited structure of PDB entry 7m0t contains 1 copy of Pfam domain PF00069 (Protein kinase domain) in Dual specificity mitogen-activated protein kinase kinase 1. Showing 1 copy in chain A [auth B].](https://www.ebi.ac.uk/pdbe/static/entry/7m0t_1_B_Pfam_PF00069_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7m0t</span> contains 1 copy of Pfam domain <span class='highlight'>PF00069 (Protein kinase domain)</span> in <span class='highlight'>Dual specificity mitogen-activated protein kinase kinase 1</span>. Showing 1 copy in chain <span class='highlight'>A [auth B]</span>.")
![The deposited structure of PDB entry 7m0t contains 1 copy of Pfam domain PF07714 (Protein tyrosine and serine/threonine kinase) in Serine/threonine-protein kinase B-raf. Showing 1 copy in chain B [auth A].](https://www.ebi.ac.uk/pdbe/static/entry/7m0t_2_A_Pfam_PF07714_image-200x200.png "The deposited structure of PDB entry <span class='highlight'>7m0t</span> contains 1 copy of Pfam domain <span class='highlight'>PF07714 (Protein tyrosine and serine/threonine kinase)</span> in <span class='highlight'>Serine/threonine-protein kinase B-raf</span>. Showing 1 copy in chain <span class='highlight'>B [auth A]</span>.")
InterPro annotations