› 7m17

Electron Microscopy
3.65Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo hexamer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-182395 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Volume-regulated anion channel subunit LRRC8A Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 819 amino acids
Theoretical weight: 95.26 KDa
Source organism: Mus musculus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q80WG5 (Residues: 1-810; Coverage: 100%)
Gene names: Lrrc8, Lrrc8a, Swell1
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand PEE 18 x PEE
Ligand YNJ 1 x YNJ
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.65Å
Relevant EMDB volumes: EMD-23614
Expression system: Spodoptera frugiperda

Quick links

Citations

2 review citations

A SWELL time to develop the molecular pharmacology of the volume-regulated anion channel (VRAC).
Figueroa et al. (2022)
1 more

1 mention without citation

Recent Advances in the Structural Biology of the Volume-Regulated Anion Channel LRRC8.
Kasuya et al. (2022)