› 7m1q

Electron Microscopy
2.92Å resolution

Human ABCA4 structure in complex with N-ret-PE

Released:
DOI: 10.2210/pdb7m1q/pdb
PDB entry 7m1q coloured by chain, front view.
PDB entry 7m1q coloured by chain, side view.
PDB entry 7m1q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Cryo-EM structures of the ABCA4 importer reveal mechanisms underlying substrate binding and Stargardt disease.
Scortecci JF, Molday LL, Curtis SB, Garces FA, Panwar P, Van Petegem F, Molday RS
OpenAccess logo Nat Commun 12 5902 (2021)
PMID: 34625547
Related structures: EMD-23618

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160256 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (3 distinct):
Retinal-specific phospholipid-transporting ATPase ABCA4 Chain: A
Molecule details ›
Chain: A
Length: 2273 amino acids
Theoretical weight: 256.2 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P78363 (Residues: 1-2273; Coverage: 100%)
Gene names: ABCA4, ABCR
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG, BMA, MAN
Ligand NAG 2 x NAG
Ligand BMA 1 x BMA
Ligand MAN 2 x MAN
Carbohydrate polymer : NEW Components: NAG, BMA
Ligand NAG 2 x NAG
Ligand BMA 1 x BMA
3 bound ligands:
Ligand NAG 6 x NAG
Ligand HZL 1 x HZL
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.92Å
Relevant EMDB volumes: EMD-23618
Expression system: Homo sapiens

Quick links

Citations

1 review citation

Recent advances in membrane mimetics for membrane protein research.
Young JW. (2023)
12 other articles

4 mentions without citation

Binding mode analysis of ABCA7 for the prediction of novel Alzheimer's disease therapeutics.
Namasivayam et al. (2021)
3 more