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Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii.

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Zhang Z, Morgan CE, Bonomo RA, Yu EW
OpenAccess logo mBio 12 e0103121 (2021)
Related entries: 7m4p, 7m4q, 7m4u, 7m4w, 7m4x, 7m4y, 7m4z

Cited: 24 times
EuropePMC logo PMID: 34044590

Abstract

Antibiotic-resistant strains of the Gram-negative pathogen Acinetobacter baumannii have emerged as a significant global health threat. One successful therapeutic option to treat bacterial infections has been to target the bacterial ribosome. However, in many cases, multidrug efflux pumps within the bacterium recognize and extrude these clinically important antibiotics designed to inhibit the protein synthesis function of the bacterial ribosome. Thus, multidrug efflux within A. baumannii and other highly drug-resistant strains is a major cause of failure of drug-based treatments of infectious diseases. We here report the first structures of the

Articles - 7m4v mentioned but not cited (2)

  1. Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii. Zhang Z, Morgan CE, Bonomo RA, Yu EW. mBio 12 e0103121 (2021)
  2. Structural conservation of antibiotic interaction with ribosomes. Paternoga H, Crowe-McAuliffe C, Bock LV, Koller TO, Morici M, Beckert B, Myasnikov AG, Grubmüller H, Nováček J, Wilson DN. Nat Struct Mol Biol 30 1380-1392 (2023)


Reviews citing this publication (7)

  1. Drug‑resistant Acinetobacter baumannii: From molecular mechanisms to potential therapeutics (Review). Wu HJ, Xiao ZG, Lv XJ, Huang HT, Liao C, Hui CY, Xu Y, Li HF. Exp Ther Med 25 209 (2023)
  2. Exploring the Structural Variability of Dynamic Biological Complexes by Single-Particle Cryo-Electron Microscopy. DiIorio MC, Kulczyk AW. Micromachines (Basel) 14 118 (2022)
  3. Bacterial effluxome as a barrier against antimicrobial agents: structural biology aspects and drug targeting. Brindangnanam P, Sawant AR, Prashanth K, Coumar MS. Tissue Barriers 10 2013695 (2022)
  4. Types and Mechanisms of Efflux Pump Systems and the Potential of Efflux Pump Inhibitors in the Restoration of Antimicrobial Susceptibility, with a Special Reference to Acinetobacter baumannii. Zack KM, Sorenson T, Joshi SG. Pathogens 13 197 (2024)
  5. Molecular insights into the determinants of substrate specificity and efflux inhibition of the RND efflux pumps AcrB and AdeB. Wilhelm J, Pos KM. Microbiology (Reading) 170 (2024)
  6. Structural and functional diversity of Resistance-Nodulation-Division (RND) efflux pump transporters with implications for antimicrobial resistance. Kavanaugh LG, Dey D, Shafer WM, Conn GL. Microbiol Mol Biol Rev 88 e0008923 (2024)
  7. Structural analysis of resistance-nodulation cell division transporters. Klenotic PA, Yu EW. Microbiol Mol Biol Rev 88 e0019823 (2024)

Articles citing this publication (15)



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