› 7mc2

Solution NMR

Solution structure of Miz-1 Zinc finger 11 H586Y

Released:
DOI: 10.2210/pdb7mc2/pdb
PDB entry 7mc2 coloured by chain, ensemble of 20 models, front view.
PDB entry 7mc2 coloured by chain, ensemble of 20 models, side view.
PDB entry 7mc2 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Zinc Fingers 10 and 11 of Miz-1 undergo conformational exchange to achieve specific DNA binding.
Boisvert O, Létourneau D, Delattre P, Tremblay C, Jolibois É, Montagne M, Lavigne P
Structure 30 623-636.e5 (2022)
PMID: 34963061

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171530 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Zinc finger and BTB domain-containing protein 17 Chain: A
Molecule details ›
Chain: A
Length: 85 amino acids
Theoretical weight: 9.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13105 (Residues: 556-639; Coverage: 11%)
Gene names: MIZ1, ZBTB17, ZNF151, ZNF60
Sequence domains: Zinc finger, C2H2 type

Ligands and Environments

1 bound ligand:
Ligand ZN 1 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 85%
Refinement method: simulated annealing
Expression system: Escherichia coli

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