7mff

Electron Microscopy
3.89Å resolution

Dimeric (BRAF)2:(14-3-3)2 complex bound to SB590885 Inhibitor

Released:
Source organism: Homo sapiens
Related structures: EMD-23815

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
PDBe Complex ID:
PDB-CPX-147200 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
14-3-3 protein zeta/delta Chains: C, D
Molecule details ›
Chains: C, D
Length: 245 amino acids
Theoretical weight: 27.78 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P63104 (Residues: 1-245; Coverage: 100%)
Gene name: YWHAZ
Sequence domains: 14-3-3 protein
Serine/threonine-protein kinase B-raf Chains: A, B
Molecule details ›
Chains: A, B
Length: 766 amino acids
Theoretical weight: 84.7 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P15056 (Residues: 1-766; Coverage: 100%)
Gene names: BRAF, BRAF1, RAFB1
Sequence domains:

Ligands and Environments

1 bound ligand:
1 modified residue:

Experiments and Validation Details

Entry percentile scores
Resolution: 3.89Å
Relevant EMDB volumes: EMD-23815
Expression system: Homo sapiens