› 7min

Electron Microscopy
3.09Å resolution

Mouse TRPV3 in cNW11 nanodiscs, closed state at 42 degrees Celsius

Released:
DOI: 10.2210/pdb7min/pdb
PDB entry 7min coloured by chain, front view.
PDB entry 7min coloured by chain, side view.
PDB entry 7min coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI
Nat Struct Mol Biol 28 564-572 (2021)
PMID: 34239124
Related structures: EMD-23857

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185081 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 808 amino acids
Theoretical weight: 92.63 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8K424 (Residues: 1-791; Coverage: 100%)
Gene name: Trpv3
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand POV 36 x POV
Ligand NA 4 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.09Å
Relevant EMDB volumes: EMD-23857
Expression system: Homo sapiens

Quick links

Citations

10 review citations

Insights into the Role of Membrane Lipids in the Structure, Function and Regulation of Integral Membrane Proteins.
Renard et al. (2021)
9 more

10 mentions without citation

Intraindividual variability of sleep/wake patterns in relation to child and adolescent functioning: A systematic review.
Becker et al. (2017)
9 more