› 7mio

Electron Microscopy
3.48Å resolution

Mouse TRPV3 in cNW11 nanodiscs, open state at 42 degrees Celsius

Released:
DOI: 10.2210/pdb7mio/pdb
PDB entry 7mio coloured by chain, front view.
PDB entry 7mio coloured by chain, side view.
PDB entry 7mio coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
Nadezhdin KD, Neuberger A, Trofimov YA, Krylov NA, Sinica V, Kupko N, Vlachova V, Zakharian E, Efremov RG, Sobolevsky AI
Nat Struct Mol Biol 28 564-572 (2021)
PMID: 34239124
Related structures: EMD-23858

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-185081 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transient receptor potential cation channel subfamily V member 3 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 808 amino acids
Theoretical weight: 92.63 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q8K424 (Residues: 1-791; Coverage: 100%)
Gene name: Trpv3
Sequence domains:

Ligands and Environments

2 bound ligands:
Ligand POV 28 x POV
Ligand NA 1 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 3.48Å
Relevant EMDB volumes: EMD-23858
Expression system: Homo sapiens

Quick links

Citations

11 review citations

Insights into the Role of Membrane Lipids in the Structure, Function and Regulation of Integral Membrane Proteins.
Renard et al. (2021)
10 more

5 mentions without citation

Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel.
Nadezhdin et al. (2021)
4 more