› 7mj8

X-ray diffraction
1.79Å resolution

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
PDBe Complex ID:
PDB-CPX-495123 (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Ig-like domain-containing protein Chain: A
Molecule details ›
Chain: A
Length: 277 amino acids
Theoretical weight: 32.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: A0A140T913 (Residues: 25-300; Coverage: 80%)
Gene name: HLA-A
Sequence domains:
Beta-2-microglobulin Chain: B
Molecule details ›
Chain: B
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Sequence domains: Immunoglobulin C1-set domain
Insulin-like growth factor-binding protein-like 1 Chain: C
Molecule details ›
Chain: C
Length: 12 amino acids
Theoretical weight: 1.26 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8WX77 (Residues: 14-25; Coverage: 0%)
Gene names: IGFBPL1, IGFBPRP4

Ligands and Environments

1 bound ligand:
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: C2
Unit cell:
a: 111.7Å b: 79.02Å c: 60.24Å
α: 90° β: 97.14° γ: 90°
R-values:
R R work R free
0.156 0.154 0.19
Expression systems:
  • Escherichia coli
  • Not provided

Quick links

Citations

30 review citations

CAR immune cells: design principles, resistance and the next generation.
Labanieh et al. (2023)
29 more

2 mentions without citation

Cross-HLA targeting of intracellular oncoproteins with peptide-centric CARs.
Yarmarkovich et al. (2021)
1 more