› 7mjg

Electron Microscopy
2.81Å resolution

Cryo-EM structure of the SARS-CoV-2 N501Y mutant spike protein ectodomain

Released:
DOI: 10.2210/pdb7mjg/pdb
PDB entry 7mjg coloured by chain, front view.
PDB entry 7mjg coloured by chain, side view.
PDB entry 7mjg coloured by chain, top view.
Source organism: Severe acute respiratory syndrome coronavirus 2
Primary publication:
Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies.
Zhu X, Mannar D, Srivastava SS, Berezuk AM, Demers JP, Saville JW, Leopold K, Li W, Dimitrov DS, Tuttle KS, Zhou S, Chittori S, Subramaniam S
OpenAccess logo PLoS Biol 19 e3001237 (2021)
PMID: 33914735
Related structures: EMD-23872

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-144650 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Spike glycoprotein Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 1288 amino acids
Theoretical weight: 142.48 KDa
Source organism: Severe acute respiratory syndrome coronavirus 2
Expression system: Homo sapiens
UniProt:
  • Canonical: P0DTC2 (Residues: 1-1208; Coverage: 95%)
Gene names: 2, S
Sequence domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: NAG
Carbohydrate polymer
1 bound ligand:
Ligand NAG 24 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
Resolution: 2.81Å
Relevant EMDB volumes: EMD-23872
Expression system: Homo sapiens

Quick links

Citations

32 review citations

The biological and clinical significance of emerging SARS-CoV-2 variants.
Tao et al. (2021)
31 more

9 mentions without citation

Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies.
Zhu et al. (2021)
8 more